In high spatial resolution (HSR) imagery scene classification, it is a challenging task to recognize the high-level semantics from a large volume of complex HSR images. The probabilistic topic model (PTM), which focuses on modeling topics, has been proposed to bridge the so-called semantic gap. Conventional PTMs usually model the images with a dense semantic representation and, in general, one topic space is generated for all the different features. However, this approach fails to consider the sparsity of the semantic representation, the classification quality, as well as the time consumption. In this paper, to solve the above problems, a fully sparse semantic topic model (FSSTM) framework is proposed for HSR imagery scene classification. FSSTM, with an elaborately designed modeling procedure, is able to represent the image with sparse but representative semantics. Based on this framework, the topic weights of multiple features are exploited by solving a concave maximization problem, which improves the fusion of the discriminative semantic information at the topic level. Meanwhile, the sparsity and representativeness of the topics generated by FSSTM guarantee that the image is adaptive to the change of a topic number. FSSTM can consistently achieve a good performance with a limited number of training samples, and is robust for HSR image scene classification. The experimental results obtained with three different types of HSR image data sets confirm that the proposed algorithm is effective in improving the performance of scene classification, and is highly efficient in discovering the semantics of HSR images when compared with the state-of-the-art PTM methods.